Week 17 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay pays 25-1

Green Bay Packers are 3-point favorites against Minnesota Vikings in the NFL's Week 17. The advanced computer model simulates every NFL game 10,000 times and has won over $7,700 for $100 players on its top-rated NFL picks since its inception. It has picked the Packers to win three straight games and beat Miami on Christmas Day. SportsLine's model has five confident NFL best bets for Week17.

The advanced model simulates every NFL game 10,000 times and it's high on the San Francisco 49ers to cover against the Las Vegas Raiders. Las Nevada has lost two of its last three games, including a crushing loss at Pittsburgh on Christmas Eve. San Francians are on an eight-game winning streak.

The advanced model predicts a 5-way football parlay that pays 25-1. It also has a pair of underdogs that have a chance to win outright.