Week 1 NFL picks, odds, 2023 best bets from proven model: This 5-way football parlay pays out 25-1

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Week 1 NFL picks, odds, 2023 best bets from proven model: This 5-way football parlay pays out 25-1

With only one week until the start of the NFL season, bettors everywhere are scouring the Week 1 NFL lines and putting together their opening-week NFL bets. The latest Week 1 NFL odds from the SportsLine Consensus lists the Carolina Panthers as 3.5-point underdogs on the road against the Atlanta Falcons as Bryce Young makes his NFL debut. Young won a Heisman Trophy at Alabama and Carolina made a move up to select him No. 1 overall in the 2023 NFL Draft. The Bears will have interest in that game as the owner of Carolina's first-round pick next year, but their primary task is hosting the Packers for the 207th all-time meeting in the NFL's oldest rivalry.

Chicago is a two-point home favorite in this week's NFL spreads, but should you include them in your Week 1 NFL bets and NFL parlays? Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of this season.  

The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 1. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 1 NFL picks at SportsLine.

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the San Francisco 49ers (-2.5) to cover on the road over the Pittsburgh Steelers. These are two of the proudest franchises in the NFL, but they're in different phases at the moment, with San Francisco at the start of a new title window now that Brock Purdy has been unearthed, while Pittsburgh is still trying to figure out life after Ben Roethlisberger with Kenny Pickett entering his second season.

The Steelers went 7-5 with Pickett as a starter during his rookie year, but Pittsburgh fell short of the postseason despite closing the year by winning six of seven. Meanwhile, after fears all offseason that Purdy might not recover from elbow surgery in time for Week 1, the last pick in the 2022 NFL Draft appears on track to start and San Francisco will hope the magical seven-game stretch he carried them through was no fluke.

The model is expecting a defensive battle with a pair of defenses that ranked top 10 in the NFL in points allowed, predicting that under 40.5 hits over 60% of the time. However, the San Francisco defense reigns supreme, limiting the Steelers to fewer than 300 yards of total offense to help the 49ers cover the spread in well over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a pair of underdogs that have a chance to win outright. You can only see the model's NFL Week 1 best bets and parlay at SportsLine

What are the model's top Week 1 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 163-113 run on its top-rated picks, and find out.